应用中医传承辅助平台分析冠心病不稳定型心绞痛方剂的组方用药规律
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篇名: 应用中医传承辅助平台分析冠心病不稳定型心绞痛方剂的组方用药规律
TITLE:
摘要: 目的:为深度挖掘中医药治疗冠心病不稳定型心绞痛和新药研发提供参考依据。方法:应用中医传承辅助平台软件,构建中医药治疗冠心病不稳定型心绞痛的组方数据库,采用软件的临床采集、平台管理、资料管理、知识检索、统计报表、数据分析功能,对方剂数据库进行四气、五味、归经分布、频次统计、组方规律、潜在新方等分析。结果:通过对治疗冠心病不稳定型心绞痛的178首方剂分析,涉及中药152味。四气分布频次前3位的分别是温(617)、寒(474)和平(288);五味分布频次前3位的分别是苦(750)、甘(732)和辛(497);归经分布频次前3位的分别为肝(860)、心(573)和脾(549)。出现频次高于10次的中药共40味,前5位分别是川芎、丹参、黄芪、当归和红花。依据药物组合出现的频次从高到低排列,前5位分别是川芎-丹参、川芎-当归、川芎-黄芪、红花-川芎和丹参-黄芪。演化得到新方共8首。结论:中国知网中收录治疗冠心病不稳定型心绞痛以药性多偏温平,药味甘苦,用药多选活血通经、祛瘀止痛、除烦安神等功效为主,体现了冠心病不稳定型心绞痛的“标本同治,补泻兼施”的治疗原则。
ABSTRACT: OBJECTIVE: To provide reference for TCM in the treatment of coronary heart disease (CHD) unstable angina and new drug research and development. METHODS: TCM inheritance auxiliary platform software was adopted to build prescription database of TCM in the treatment of CHD unstable angina. The software function of clinical collection, platform management, information management, knowledge retrieval, statistics, data analysis were adopted to analyze prescription database in respects of four properties, five tastes, channel tropism distribution, frequency statistics, rules of prescriptions and potential new prescriptions, etc. RESULTS: Through analyzing 178 prescriptions of CHD unstable angina, 152 ingredients were involved. Top 3 in the list of distribution frequency of four properties were warm (617), cold (474) and mild (288). Top 3 in the list of distribution frequency of five tastes were bitter (750), sweet (732) and pungent (497). Top 3 in the list of distribution frequency of channel tropism were liver (860), heart (573) and spleen (549). A total of 40 ingredients were used more than 10 times, and top 5 were Ligusticum chuanxiong, Salvia miltiorrhiza, Astragalus membranaceus, Angelica sinensis and Carthamus tinctorious. According to the frequency of the drug combination, top 5 in descending order were L.chuanxiong-S. miltiorrhiza, L. chuanxiong-A. sinensis, L. chuanxiong-A. membranaceus, C. tinctorious-L. chuanxiong and S. miltiorrhiza-A. membranaceus. A total of 8 new prescriptions were obtained after evolution. CONCLUSIONS: Main prescriptions for CHD unstable angina included in CNKI are mild drug property, sweetness and bitterness in taste. Main selected ingredients can promote blood circulation, remove blood stasis and relieve pain, relieve restlessness and tranquilize the mind. It embodies the CHD unstable angina treatment principles of “treat both the incidental and fundamental aspects, tonification and purgation in combination”.
期刊: 2017年第28卷第32期
作者: 侯王君,庄贺,薛一涛,刘伟,夏明峰,庄慧魁
AUTHORS: HOU Wangjun,ZHUANG He,XUE Yitao,LIU Wei,XIA Mingfeng,ZHUANG Huikui
关键字: 冠心病不稳定型心绞痛;中医传承辅助平台;方剂;组方规律
KEYWORDS: Coronary heart disease unstable angina; TCM inheritance auxiliary platform; Prescription; Regularity
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