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异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学评价
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| 篇名： | 异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学评价 |
| TITLE： | Pharmacoeconomic Evaluation of Magnesium Isoglycyrrhizinate Preventing Liver Damage Induced by Chemo- therapeutic Drugs for Gastric Cancer |
| 摘要： | 目的：评价异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学，为临床合理选用保肝药提供参考。方法：回顾性收集2018年1月－2020年2月我院200例住院患者的病历，分为A组（预防性使用异甘草酸镁，50例）、B组（预防性使用异甘草酸镁联合中药协定方，50例）、C组（预防性使用多烯磷脂酰胆碱，50例）和D组（未预防性使用保肝药，50例）。比较4种方案预防肝损伤的效果（总有效率），采用最小成本法和成本-效果分析法进行经济学评价，同时进行敏感性分析。结果：A、B、C、D组患者总有效率分别为94.00％、96.00％、82.00％、72.00％，A组和B组患者的总有效率比较差异无统计学意义（P＞0.05），但显著高于C组和D组（P＜0.05）；C组患者总有效率显著高于D组（P＜0.05）。A、B、C、D组的成本分别为1936.70、2086.96、1800.91、2975.42元，采用最小成本法比较A组和B组方案，结果A组方案更经济；采用成本-效果法比较C组和D组方案，结果C组方案更经济；采用成本-效果法比较A组和C组方案，结果两组方案的成本-效果比分别为2060.32、2196.23，A组方案的增量成本-效果比为1131.58，A组方案更经济。敏感性分析支持上述结果。结论：异甘草酸镁预防胃癌化疗药物致肝损伤的成本-效果优于异甘草酸镁联合中药协定方、多烯磷脂酰胆碱和未预防性使用保肝药，更具经济学优势。 |
| ABSTRACT： | OBJECTIVE：To ev aluate pha rmacoeconomics of magnesium isoglycyrrhizinate preventing liver damage induced by chemotherapeutic drugs for gastric cancer ，and to provide reference for rational use of liver-protecting drugs. METHODS ：Totally 200 inpatient medical records were collected from our hospital retrospectively during Jan. 2018-Feb. 2020，and then divided into group A （prophylactic use of magnesium isoglycolate ，50 cases），group B （prophylactic use of magnesium isoglycolate combined with TCM prescriptions ，50 cases），group C （prophylactic use of polyene phosphatidylcholine ，50 cases） and group D （non-prophylactic use of liver-protection drugs ，50 cases）. The effects （total response rate ）of four plans preventing liver damage were evaluated. Pharmacoeconomic evaluation was analyzed by cost-minimization analysis and cost-effectiveness method ， sensitivity analysis was carried out at the same time . RESULTS ：Total response rates of group A ，B，C and D were 94.00％， 96.00％，82.00％ and 72.00％. The total response rates of group A and B had no statistical significance （P＞0.05），but were significantly higher than those of group C and D （P＜0.05）；total response rate of group C was significantly higher than that of group D （P＜0.05）. The costs of groups A ，B，C and D were 1 936.70，2 086.96，1 800.91，2 975.42 yuan. The cost-minimization analysis was used to compare the therapeutic plan of group A and B ，and plan of group A was more economical. The cost-effectiveness method was used to compare therapeutic plan between group C and D ，and the plan of group C was more economical. The cost-effectiveness method was used to compare therapeutic plan between group A and C ，and the cost-effectiveness ratio of 2 groups were 2 060.32 and 2 196.2 3，incremental cost-effectiveness ratio was 1 131.58，and the plan of group A was more economical. Above conclusion were supported by the results of sensitivity analysis. CONCLUSIONS ：The cost-effectiveness of magnesium isoglycyrrhizinate preventing liver damage induced by chemotherapeutic drugs for gastric cancer is better than magnesium isoglycyrrhizinate combined with TCM prescription ， polyene phosphatidylcholine and non-prophylactic use of liver-protecting drugs ，showing economical advantage. |
| 期刊： | 2020年第31卷第13期 |
| 作者： | 任发燕，王超，谭喜莹，王海丹 |
| AUTHORS： | REN Fayan，WANG Chao，TAN Xiying ，WANG Haidan |
| 关键字： | 异甘草酸镁；药物性肝损伤；胃癌；化疗药物；药物经济学 |
| KEYWORDS： | Magnesium isoglycyrrhizina te；Drug-induced liver damage ；Gastic cancer ；Chemotherapeytic drug ；Pharmacoeconomics |
| 阅读数： | 397 次 |
| 本月下载数： | 4 次 |
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