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黄丝郁金产地加工与饮片炮制工艺的一体化研究
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| 篇名： | 黄丝郁金产地加工与饮片炮制工艺的一体化研究 |
| TITLE： | Study on integrated technology of producing area processing and decoction pieces processing of Curcuma longa |
| 摘要： | 目的 优化黄丝郁金产地加工与饮片炮制的一体化工艺（以下简称“一体化炮制工艺”）。方法按热浸法测定黄丝郁金中醇溶性浸出物的含量，采用高效液相色谱法测定姜黄素、去甲氧基姜黄素和双去甲氧基姜黄素的含量；在确定产地加工工艺的基础上，以醇溶性浸出物及姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素含量的总评归一（OD）值为考察指标，切片含水量、切片厚度、干燥温度为考察因素，以单因素实验结合星点设计-响应面法优化黄丝郁金的炮制工艺并验证，同时与按2020年版《中国药典》（一部）方法制备的黄丝郁金传统饮片进行比较。结果最优一体化炮制工艺为取新鲜黄丝郁金药材，置于沸水中煮5min，于50℃烘箱中干燥至切片含水量40％，切2mm片，再置于50℃烘箱中干燥至饮片含水量≤15.0％。经实验验证，醇溶性浸出物及姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素含量的平均OD值（0.8113，RSD＝2.13％）与预测值（0.8481）的偏差为4.34％。与传统炮制工艺所得饮片比较，一体化炮制工艺所得黄丝郁金饮片中醇溶性浸出物及姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素含量的OD值均较高。结论优化所得一体化炮制工艺操作简便且稳定、可行。 |
| ABSTRACT： | OBJECTIVE To op timize the i ntegrated technology of producing area processing and decoction pieces processing of Curcuma longa （hereinafter refer to “integrated technology ”）. METHODS The content of ethanol-soluble extract in C. longa was determined by hot leaching method ；the contents of curcumin ，demethoxycurcumin and bisdemethoxycurcumin were determined by high performance liquid chromatography. On the basis of identification of producing area processing technology ， Using overall desirability （OD） value of the contents of ethanol-soluble extract ， curcumin， demethoxycurcumin and bisdemethoxycurcumin as evaluation indexes ，moisture content ，slice thickness and drying temperature as factors ，the integrated technology of C. longa was optimized by single factor tests combined with central composite design-response surface method ，and the validation tests were conducted. At the same time ，prepared product was compared with traditional decoction pieces prepared according to 2020 edition of Chinese Pharmacopoeia （part Ⅰ）. RESULTS The best integrated technology was that the fresh C. longa was boiled in boiling water for 5 min，dried at 50 ℃ to 40％ water content ，cut into 2 mm thin slices ，and dried at 50 ℃ until moisture content not exceeding 15.0％. After validation ，The deviation between the average OD value （0.811 3，RSD＝2.13％） and the predicted value （0.848 1）of the contents of ethanol-soluble extract ，curcumin，demethoxycurcumin and bisdemethoxycurcumin was 4.34％. OD value of the contents of ethanol-soluble extract ，curcumin，demethoxycurcumin and bisdemethoxycurcumin in decoction pieces prepared by integrated technology were all higher than those prepared by traditional technology. CONCLUSIONS The process optimized in this study is simple ，stable and feasible. |
| 期刊： | 2022年第33卷第02期 |
| 作者： | 敖明月，彭颖，东宝花，蒋云秀，廖宇娇，余凌英，陈志敏，胡昌江 |
| AUTHORS： | AO Mingyue， PENG Ying，DONG Baohua，JIANG Yunxiu，LIAO Yujiao，YU Lingying，CHEN Zhimin，HU Changjiang |
| 关键字： | 黄丝郁金；产地加工与饮片炮制工艺一体化；星点设计-响应面法；含量测定；总评归一值 |
| KEYWORDS： | Curcuma longa ；integrated technology of producing area processing and decoction pieces processing ；central |
| 阅读数： | 226 次 |
| 本月下载数： | 4 次 |
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