粤八味的药理作用与安全性研究进展
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篇名: | 粤八味的药理作用与安全性研究进展 |
TITLE: | Research progress of pharmacological effects and security of Yuebawei |
摘要: | 粤八味是指化橘红、广陈皮、阳春砂、广藿香、巴戟天、沉香、广佛手、何首乌8种岭南道地药材。本综述结果显示,粤八味的药理作用非常广泛,在止咳化痰、抗菌抗炎、增强机体免疫力、抗氧化、抗抑郁、免疫调节及调理肠胃功能等方面有显著作用,其开发应用前景广阔,但现有药理研究大部分都只停留在药效学研究基础上。在粤八味安全性研究方面,除何首乌的肝毒性研究较多外,其他药材的安全性研究较少;同时,关于粤八味与其他地产药材在临床应用上的疗效比较研究也较少。今后有必要加强对粤八味药效物质基础、药理作用机制及临床用药安全性和疗效观察的研究,为粤八味的新药开发及临床推广应用提供科学依据。 |
ABSTRACT: | Yuebawei refers to 8 kinds of genuine medicinal materials in south China area,namely Citri Grandis Exocarpium, Citrus reticulata, Amomum villosum, Pogostemon cablin, Morinda officinalis, Aquilaria sinensis, Citrus medica and Polygonum multiflorum. The results of this review show that, the pharmacological effects of Yuebawei are very extensive. It has significant effects in relieving cough and phlegm, anti-bacterial and anti-inflammatory, enhancing immunity, anti-oxidation, antidepressant, immune regulation and regulating gastrointestinal function. Its development and application prospects are broad, but most of the existing pharmacological studies stay on pharmacodynamic studies. In the aspect of the safety research of Yuebawei, there are few studies on the safety of other medicinal materials, except for the liver toxicity of P. multiflorum; at the same time, there are few comparative studies on the therapeutic advantages of Yuebawei and other local medicinal materials in clinical application. It is necessary to strengthen the research on the material basis of pharmacological action mechanism, and safety and efficacy observation of clinical medication for Yuebawei, so as to provide scientific basis for the development of new drugs and clinical promotion and application of Yuebawei. |
期刊: | 2022年第33卷第23期 |
作者: | 万诗雨,黄冉,杨得坡,杨洋,陈希瑜,陈琴华,梅全喜 |
AUTHORS: | WAN Shiyu,HUANG Ran,YANG Depo,YANG Yang,CHEN Xiyu,CHEN Qinhua,MEI Quanxi |
关键字: | 道地药材;粤八味;药理作用;安全性 |
KEYWORDS: | genuine medicinal material; Yuebawei; |
阅读数: | 828 次 |
本月下载数: | 6 次 |
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