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中药复方配伍机制研究方法/策略进展
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| 篇名： | 中药复方配伍机制研究方法/策略进展 |
| TITLE： | Progress in research methods or strategies of compatibility mechanism of traditional Chinese medicine prescriptions |
| 摘要： | 中药复方即方剂，是指在辨证论治的基础上依据病情的需要，有选择地将药物按照一定的配伍原则组合而成的用药形式。目前中药复方配伍机制的研究方法/策略主要围绕药效物质分析（包括中药化学成分分析、入血药源成分分析、药动学分析）和药理信号通路分析（包括网络药理学分析、信号通路指标检测、代谢组学分析）两方面进行。在今后的研究中，应以“七情和合”“升降浮沉“”君臣佐使“”四气五味”为基础探究中药复方的配伍关系，并体现中药复方配伍与药物化学成分、药动学、药理通路机制的变化规律及各中药不同配伍比例时化学成分的变化规律，在保证中药复方整体疗效的基础上，挖掘中药复方配伍机制内涵，为优化中药复方的临床应用提供参考，也为创造新的中药复方提供思路。 |
| ABSTRACT： | Compound formulas of traditional Chinese medicines （TCM）， also known as prescription in clinic， refers to a form of medication in which several TCMs are selectively combined according to the certain compatibility principles and the needs of patient’s condition， based on syndrome differentiation and treatment. At present， the methods and strategies for investigating the compatibility mechanisms of TCM prescriptions mainly focus on the following two aspects: analysis of pharmacological substances （including chemical composition analysis of TCM， ingredients of TCM analysis in blood， and pharmacokinetic analysis） and pharmacological signaling pathways analysis （involving network pharmacology analysis， signal pathway indicator detection， and metabolomics analysis）. In future research， the compatibility relationships of TCM prescriptions should be explored according to the principles of “Qiqing Hehe”，“ Shengjiang Fuchen”，“ Junchen Zuoshi”， and “Siqi Wuwei”. The regularity of TCM prescriptions compatibility should be shown in the change regularity of chemical components， pharmacokinetics， pharmacological pathways， and chemical compositions of various ratios of TCMs. Based on the insurance of holistic efficacy of TCM prescriptions， the underlying mechanisms of compatibility should be uncovered， which will provide references for the optimization of clinical applications of prescriptions and new directions for the creation of innovative TCM prescriptions. |
| 期刊： | 2023年第34卷第11期 |
| 作者： | 字磊；李艳娟；李艳芹；王涛；郝俊杰；俞捷；杨兴鑫 |
| AUTHORS： | ZI Lei，LI Yanjuan，LI Yanqin，WANG Tao，HAO Junjie，YU Jie，YANG Xingxin |
| 关键字： | 中药复方；配伍机制；药效物质；研究方法；研究策略 |
| KEYWORDS： | prescription of traditional Chinese medicines； compatibility mechanism； pharmacodynamic substances； research |
| 阅读数： | 206 次 |
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