莫西沙星致老年患者不良反应报告293例分析
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篇名: | 莫西沙星致老年患者不良反应报告293例分析 |
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摘要: | 目的:了解莫西沙星致老年患者药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:采用回顾性调查法,对2014年度北京市ADR监测中心接收的莫西沙星所致的老年患者ADR报告数据按照年龄、性别、给药途径、合并用药情况、ADR主要临床表现等进行统计、分析。结果:293例ADR中,以男性居多(55.63%),70~79岁老年患者发生ADR较多(35.84%);临床表现多为皮肤及其附件损害(30.07%)、中枢及外周神经系统损害(27.68%)、心血管系统损害(13.37%)和胃肠系统损害(10.74%),其中以皮疹、瘙痒、头晕、心悸、恶心等最为显著;ADR发生时间多在24 h以内(56.31%);静脉给药ADR发生率远大于口服给药发生率(92.15% vs. 7.85%)。严重ADR 16例,其中死亡2例。结论:临床应重视莫西沙星在老年患者中引起的ADR,警惕严重ADR的发生。 |
ABSTRACT: | OBJECTIVE: To investigate the characteristics and clinical manifestations of adverse drug reaction(ADR) related to moxifloxacin on elderly patients, and provide references for clinical drug. METHODS: Moxifloxacin-induced ADR reports of elderly patients collected by Beijing ADR Monitoring Center in 2012 were analyzed statistically. RESULTS: Among 293 ADR cases, there were a majority of male patients (55.63%), mainly aged 70-79 years old (35.84%); main clinical manifestations were lesion of skin and its appendants (30.07%), nervous system reaction (27.68%), circulatory system damage (13.37%) and gastrointestinal system reaction (10.74%), especially rash, pruritus, palpitation, nausea, psychogeny, phlebitis. Most ADRs occurred within 24 h (56.31%). The incidence of ADR induced by intravenous administration was significantly higher than that of oral administration (92.15% vs. 7.85%). There were 16 cases of severe ADR. CONCLUSIONS: Great importance should be attached to the ADR induced by moxifloxacin in the elderly and the occurrence of serious ADR. |
期刊: | 2016年第27卷第2期 |
作者: | 曹萌萌,温爱萍 |
AUTHORS: | CAO Mengmeng,WEN Aiping |
关键字: | 莫西沙星;老年患者;药品不良反应;合理用药 |
KEYWORDS: | Moxifloxacin; Elderly patients; ADR; Rational drug use |
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