目的：测定败酱皂苷H1平衡溶解度和表观油水分配系数（lg P），为败酱皂苷后续的剂型设计和成药性研究提供参考。方

法：采用高效液相色谱-蒸发光散射检测（HPLC-ELSD）法测定败酱皂苷H1在不同有机溶剂和不同pH缓冲液中的平衡溶解度；采

用摇瓶法测定败酱皂苷H1的lg P。结果：25 ℃下败酱皂苷H1在水、甲醇和乙醇中的平衡溶解度依次为0.091 75、96.51、46.89 g/L，

在磷酸盐缓冲液pH 7.6～10.0 范围内平衡溶解度随着pH 升高而明显增大；败酱皂苷H1在pH 6.0～8.0 缓冲液中其lg P 范围为

0.695～0.773。结论：败酱皂苷H1及该类齐墩果酸型皂苷属于低溶解度、低透过性的成分，因而不适宜作为常规口服制剂开

发使用。

OBJECTIVE：To determine the solubility and apparent oil and water partition coefficient（lg P）of saponin H1，and

provide reference for dosage form design and druggability research of saponin. METHODS：HPLC-ELSD was conducted to determine

the equilibrium solubility of saponin H1 in different organic solvents and pH buffer solutions；shaking flask was applied to determine

lg P value of saponin H1. RESULTS：The equilibrium solubility of saponin H1 in water，methanol and ethanol at 25 ℃ was

0.09175 g/L，96.51 g/L and 46.89 g/L，respectively. The solubility increased apparently at high pH within pH range at 7.6-10.0；

the lg P value was between 0.695-0.773 in buffers within pH range at 6.0-8.0. CONCLUSIONS：Saponin H1 and the oleanolic acid

type saponins belong to low solubility, low transmission components, so it is not suitable for use as a conventional oral formulation

is developed.