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舒肝宁注射液对顺铂中毒小鼠肝脏损伤的保护作用
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| 篇名： | 舒肝宁注射液对顺铂中毒小鼠肝脏损伤的保护作用 |
| TITLE： | |
| 摘要： | 目的：观察舒肝宁注射液对顺铂中毒小鼠肝脏损伤的保护作用。方法：将100只小鼠随机分正常对照（生理盐水）组、模型组和舒肝宁注射液高、中、低剂量[41.5、20.8、10.4 g （生药）/kg]组，每组20只。除正常对照组外，其余各组小鼠于每周一、周四 ip顺铂（3 mg/kg）复制顺铂中毒模型，并同时于每周一至周五ip相应药物，每天1次，连续10周。测定各组小鼠血清中丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）活性和白蛋白（ALB）、总蛋白、球蛋白含量及总蛋白/球蛋白（A/G）比值，计算肝脏指数并观察肝脏组织形态。结果：与正常对照组比较，模型组小鼠血清中AST活性升高，ALB、球蛋白含量增加，A/G值升高（P＜0.01），肝组织中多见肝索界限不清、肝细胞浊肿、胞浆疏松化，肝细胞明显嗜酸性病变。与模型组比较，舒肝宁注射液低、高剂量组小鼠血清中ALB含量减少、球蛋白含量增加、A/G值升高，且舒肝宁注射液高剂量组小鼠血清中AST活性降低（P＜0.05或P＜0.01），肝组织病理形态改善。结论：舒肝宁注射液对顺铂所致小鼠肝脏损伤有一定的保护作用。 |
| ABSTRACT： | OBJECTIVE： To observe the protective effect of Shuganning injection against liver injury induced by cisplatin in mice. METHODS： 100 mice were randomized into normal control group （normal saline）， model group， Shuganning injection high-dose， medium-dose and low-dose groups [41.5， 20.8， 10.4 g （crude drug）/kg] with 20 mice in each group. Except normal control group， other groups were given cisplatin 3 mg/kg， ip， on Monday and Thursday to induce cisplatin toxicosis model； at the same time， they were given relevant medicines from Monday to Friday by intraperitoneal injection， once a day for consecutive 10 weeks. The activities of ALT and AST， the contents of albumin， total protein and globin in serum， total protein/globin （A/G） were determined， and hepatic index was calculated and hepatic histomorphology was observed. RESULTS： Compared with normal control group， the activity of AST， the contents of ALB and globin in serum and A/G all increased in model group （P＜0.01）， unclear hepatic cords range， hepatocellular albuminoid degeneration and endochylema puffing were common and obvious acidophilic change was found in hepatic tissue. Compared with model group， the serum content of ALB decreased in Shuganning injection low-dose and high-dose groups， while globin content and A/G increased； and the activity of AST in serum decreased in Shuganning high-dose group （P＜0.05 or P＜0.01）， and pathological state of hepatic tissue was improved. CONCLUSIONS： Shuganning injection possesses a protective effect on cisplatin-induced liver injury in mice. |
| 期刊： | 2016年第27卷第7期 |
| 作者： | 张瑾 |
| AUTHORS： | ZHANG Jin |
| 关键字： | 舒肝宁注射液；肝损伤；顺铂；血清；生化指标；小鼠 |
| KEYWORDS： | Shuganning injection； Liver injury； Cisplatin； Serum； Biochemical indicator； Mice |
| 阅读数： | 451 次 |
| 本月下载数： | 2 次 |
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