肠内营养与质子泵抑制剂对脑卒中患者医院获得性肺炎的影响
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篇名: | 肠内营养与质子泵抑制剂对脑卒中患者医院获得性肺炎的影响 |
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摘要: | 目的:观察肠内营养(EN)及质子泵抑制剂(PPI)对脑卒中后医院获得性肺炎(HAP)的影响。方法:收集2013年7月-2015年1月确诊为脑卒中的患者329例,按PPI与EN使用方案分为PPI组(160例)、EN组(113例)及联合组(56例)。PPI组患者口服PPI类药物,EN组患者经鼻胃管给予EN处理,联合组患者同时使用PPI及EN。观察各组患者HAP发生率及各组患者不同给药疗程和时机对HAP发生率的影响,并记录患者应激性溃疡发生率。结果:PPI组患者HAP发生率为21.88%,EN组为30.09%,联合组为57.14%,组间比较差异有统计学意义(P<0.05);PPI组HAP患者口服PPI时间为(16.21±6.84)d,未患HAP者为(5.86±2.85)d,差异有统计学意义(P<0.05);EN组HAP患者早期EN使用率为35.29%,未患HAP者为67.09%,差异有统计学意义(P<0.05);联合组患者长期PPI+非早期EN者HAP发生率为23.21%,长期PPI+早期EN者为14.29%,短期PPI+非早期EN者为10.71%,短期PPI+早期EN者为3.56%,组间比较差异有统计学意义(P<0.05);PPI组患者应激性溃疡发生率为1.88%,EN组为3.54%,联合组为12.50%,组间比较差异有统计学意义(P<0.05)。结论:早期使用EN及短期使用PPI可有效降低HAP发生率,但PPI与EN联用不能降低应激性溃疡发生率,且可能增加HAP风险。 |
ABSTRACT: | OBJECTIVE: To explore the effect of proton pump inhibitors (PPI) and enteral nutrition (EN) on the incidence rate of hospital-acquired pneumonia (HAP) after stroke. METHODS: 329 stroke patients collected during Jul. 2013 to Jan. 2015 were divided into PPI group (160 cases), EN group (113 cases), combination group (56 cases). PPI group was given PPI orally, EN group given EN via nasogastric tube, and combination group given PPI and EN. The incidence of HAP, the effects of different medication course and timing on the incidence rate of HAP were observed in all groups, and the incidence of stress ulcer was recorded. RESULTS: HAP rate was 21.88% in PPI group, 30.09% in EN group, 57.14% in combination group, with statistical significance (P<0.05). In PPI group, the course of oral PPI was (16.21±6.84)d in HAP patients and (5.86±2.85)d in patients without HAP, with statistical significance (P<0.05). In EN group, the rate of early treatment was 35.29% in HAP patients and 67.09% in patients without HAP, with statistical significance (P<0.05). In combination group, the HAP rate of long-term PPI and non-early EN was 23.12%; that of long-term PPI and early EN was 14.29%; that of short-term PPI and non-early EN was 10.71%; that of short-term PPI and early EN was 3.56%, with statistical significance among groups (P<0.05). The incidence rate of stress ulcer was 1.88% in PPI group, 3.54% in EN group, 12.50% in combination group, with statistical significance among groups (P<0.05). CONCLUSIONS: The incidence rate of HAP can be reduce effectively by early EN and short-term use of PPI, and PPI combined with EN can not reduce the incidence of stress ulcer, but increase the rate of HAP. |
期刊: | 2016年第27卷第11期 |
作者: | 胡曦丹,何金凤,王琲,杨云云,丁楠,田泾,王卓,于锋 |
AUTHORS: | HU Xidan,HE Jinfeng,WANG Bei,YANG Yunyun,DING Nan,TIAN Jing,WANG Zhuo,YU Feng |
关键字: | 质子泵抑制剂;肠内营养;医院获得性肺炎;应激性溃疡 |
KEYWORDS: | Proton pump inhibitor; Enteral nutrition; Hospital-acquired pneumonia; Stress ulcer |
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