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丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察
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| 篇名： | 丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期（AECOPD）患者的临床疗效及安全性。方法：选取AECOPD患者80例，按随机数字表法分为观察组和对照组，各40例。两组患者均采用机械通气治疗。对照组患者根据病情给予茶碱、支气管扩张剂及糖皮质激素行常规治疗；观察组患者在对照组基础上给予丹参多酚酸盐注射液200 mg，qd，ivgtt。两组患者均治疗7 d。观察两组患者临床疗效及治疗前后患者血液流变学指标，并记录机械通气时间、重症加强护理病房（ICU）滞留时间及不良反应发生情况。结果：观察组患者临床总有效率为95.00％，显著高于对照组的70.00％，差异有统计学意义（P＜0.05）。治疗前及治疗后2 d，两组患者血液流变学指标比较，差异无统计学意义（P＞0.05）；治疗后4、6 d，两组患者血液流变学指标均较治疗前有显著改善，且观察组显著优于对照组，差异有统计学意义（P＜0.05）。观察组患者机械通气时间和ICU滞留时间均显著短于对照组，差异有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：丹参多酚酸盐治疗AECOPD疗效显著，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of salvianolate in the treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. METHODS： 80 AECOPD patients were selected and randomly divided into observation group and control group， with 40 cases in each group. Both groups received mechanical ventilation. Control group was given routine treatment of theophyllinum， bronchodilators and glucocorticoid； treatment group was additionally given Salvianolate injection 200 mg，qd，ivgtt， on the basis of control group. Clinical efficacy was observed in 2 groups， blood hemorheology indexes were also observed before and after treatment. The mechanical ventilation time， ICU residence time and ADR were recorded in 2 groups. RESULTS： Clinical total effective rate of observation group was 95.00％， which was significantly higher than 70.00％ of control group， with statistical significance （P＜0.05）. Before treatment and 2 d after treatment， blood rheology indexes of treatment group were improved significantly （all P＞0.05）， and whole blood reduction viscosity of control group was improved significantly （P＜0.05）. Mechanical ventilation time and ICU residence time of treatment group was significantly shorter than that of control group （P＜0.05）. No ADR was found in 2 groups. CONCLUSIONS： Salvianolate can significantly improve the blood coagulation status of AECOPD patients receiving invasive mechanical ventilation， and has the advantages of good clinical efficacy and low cost of medical treatment. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 李树铁，汪业铭，李媛莉，陈琛，王磊，姜伟，李福龙 |
| AUTHORS： | LI Shutie，WANG Yeming，LI Yuanli，CHEN Chen，WANG Lei，JIANG Wei，LI Fulong |
| 关键字： | 丹参多酚酸盐；慢性阻塞性肺疾病急性加重期；有创机械通气；疗效 |
| KEYWORDS： | Salvianolate； AECOPD； Invasive mechanical ventilation； Clinical efficacy |
| 阅读数： | 374 次 |
| 本月下载数： | 2 次 |
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