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复方丹参滴丸联合阿司匹林治疗冠心病的临床观察
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| 篇名： | 复方丹参滴丸联合阿司匹林治疗冠心病的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨复方丹参滴丸联合阿司匹林治疗冠心病的临床疗效及安全性。方法：将120例冠心病患者采用随机数字表法分为对照组与观察组，各60例。在给予血管紧张素转换酶抑制剂、低分子肝素、β受体阻滞药、硝酸酯类药物等常规治疗基础上，对照组患者同时给予阿司匹林肠溶片口服，每次100 mg，qd；观察组患者在对照组治疗基础上给予复方丹参滴丸口服，每次270 mg，tid。两组患者均持续用药6个月。观察两组患者的临床疗效与心电图疗效，检测两组患者治疗前后的血小板参数、心功能指标、肺功能指标及冠状动脉SYNTAX评分变化，并观察不良反应发生情况。结果：治疗后，观察组患者的临床疗效有效率和心电图疗效有效率均显著高于对照组（分别为95.0％ vs. 76.67％、71.67％ vs. 51.67％），差异均有统计学意义（P＜0.05）；观察组患者的血小板最大聚集率、血浆血栓素B2水平、平均血小板体积、左室收缩末期内径、左室舒张末期内径均显著低于或小于对照组，心排血量、左室射血分数、第一秒用力呼气量及第一秒用力呼气量占用力肺活量百分率、肺一氧化碳弥散量均显著高于对照组，差异均有统计学意义（P＜0.05）；观察组患者的SYNTAX评分显著低于对照组，差异有统计学意义（P＜0.05）。两组患者的不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：复方丹参滴丸联合阿司匹林治疗冠心病，能够改善患者心肺功能和血小板参数，疗效较好，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To explore the clinical efficacy and safety of Compound danshen dropping pill combined with aspirin in the treatment of coronary heart disease （CHD）. METHODS： 120 CHD patients were divided into control group and observation group by random number table method， with 60 cases in each group. Based on routine treatment as ACEI， low molecular heparin， β receptor block and nitric acid ester， control group was additionally given Aspirin enteric coated tablet orally， 100 mg each time， qd； observation group was additionally given Compound danshen dripping pills orally， 270 mg each time， tid， on the basis of control group. Treatment of 2 groups lasted for 6 months. Clinical efficacy and ECG efficacy were observed in 2 groups. The changes of platelet parameters， heart function indexes， lung function indexes and SYNTAX score of coronary artery were detected in 2 groups before and after treatment， and the occurrence of ADR was observed. RESULTS： After treatment， the effective rates of clinical efficacy and ECG efficacy in observation group were significantly higher than in control group （95.0％ vs.76.67％， 71.67％ vs.51.67％）， with statistical significance （P＜0.05）. The platelet maximum aggregation rate， plasma thromboxane B2， mean platelet volume， left ventricular end systolic diameter and left ventricular end diastolic diameter of observation group were significantly lower or less than those of control group； the cardiac output， left ventricular ejection fraction， first second forced respiratory volume， F EV％， diffusing capacity of pulmonary carbon monoxide of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）； SYNTAX score of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Compound danshen dripping pills combined with aspirin in the treatment of CHD is safe and effective， and can improve cardiac function and platelet parameters， and prevent the occurrence of ischemic events. |
| 期刊： | 2016年第27卷第32期 |
| 作者： | 梁鹍，董守仁，彭欢，陈雅丽，孟婉玉 |
| AUTHORS： | LIANG Kun，DONG Shouren，PENG Huan，CHEN Yali，MENG Wanyu |
| 关键字： | 冠心病；复方丹参滴丸；阿司匹林；心功能；血小板参数；肺功能；疗效 |
| KEYWORDS： | Coronary heart disease； Compound danshen dropping pill； Aspirin； Heart function； Platelet parameter； Lung function； Efficacy |
| 阅读数： | 292 次 |
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