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4种用药方案治疗小儿肛周脓肿的成本-效果分析
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| 篇名： | 4种用药方案治疗小儿肛周脓肿的成本-效果分析 |
| TITLE： | |
| 摘要： | 目的：比较4种用药方案治疗小儿肛周脓肿的经济性。方法：采用回顾性研究法，将85例肛周脓肿患儿按不同用药方案分为A组（18例）、B组（10例）、C组（14例）和D组（43例），分别采用阿莫西林氟氯西林、氟氯西林、头孢硫脒、头孢孟多治疗，均以100 mg/（kg·d）的剂量静脉滴注5～7 d。比较4组患儿的临床疗效和不良反应发生情况，并采用成本-效果分析法对4种方案的经济性进行分析。结果：A、B、C、D组患儿的痊愈率分别为77.78％、80.00％、57.14％、90.70％，C组显著低于其余3组，差异有统计学意义（P＜0.05）；4组患儿均未见明显不良反应发生。A、B、C、D组方案的成本分别为3 600.86、2 913.92、3 416.19、2 981.97元，成本-效果比分别为46.30、36.42、59.79、32.88；A、C、D组相对于B组的增量成本-效果比分别为－309.43、－21.97、6.36。敏感度分析支持成本-效果分析结果。结论：采用头孢孟多治疗小儿肛周脓肿的成本-效果最好，但氟氯西林治疗该病的时间更短、总成本更低，可根据患儿具体情况选择合适的治疗方案。 |
| ABSTRACT： | OBJECTIVE： To compare economical efficiency of 4 therapeutic regimens for pediatric perianal abscess. METHODS： By retrospective study method， 85 children were divided into group A （18 cases）， B （10 cases）， C （14 cases） and D （43 cases） according to different therapeutic regimens. They were given amoxicillin-flucloxacillin， flucloxacillin， cefathiamidine and cefamandole 100 mg/（kg·d） intravenously for 5-7 d， respectively. Clinical efficacies and the occurrence of ADR were compared among 4 groups. The economical efficiency of 4 therapeutic regimens were analyzed by the method of cost-effectiveness analysis. RESULTS： For group A， B， C and D， the cure rates were 77.78％， 80.00％， 57.14％ and 90.70％， that of group C was significantly lower than those of other 3 groups， with statistical significance （P＜0.05）. No significant ADR were found in 4 groups. The costs were 3 600.86， 2 913.92， 3 416.19 and 2 981.97 yuan， and the cost-effectiveness ratios were 46.30， 36.42， 59.79 and 32.88. The incremental cost-effectiveness ratios of group A， C and D to group B were －309.43， －21.97 and 6.36. The results of cost-effectiveness analysis were supported by sensitivity analysis. CONCLUSIONS： For pediatric perianal abscess， cefamandole shows the best cost-effectiveness； but the therapeutic duration and total cost of flucloxacillin therapeutic regimen is shorter and lower. Therapeutic regimen should be selected according to children’s condition. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 林晶 |
| AUTHORS： | LIN Jing |
| 关键字： | 小儿；肛周脓肿；抗菌药物；成本-效果分析；药物经济学 |
| KEYWORDS： | Pediatric； Perianal abscess； Antibiotics； Cost-effectiveness analysis； Pharmacoeconomics |
| 阅读数： | 440 次 |
| 本月下载数： | 2 次 |
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