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清金化痰汤治疗AECOPD痰热壅肺证患者的临床观察
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| 篇名： | 清金化痰汤治疗AECOPD痰热壅肺证患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察清金化痰汤治疗慢性阻塞性肺疾病急性加重期（AECOPD）痰热壅肺证患者的临床疗效及安全性。方法：选取AECOPD痰热壅肺证患者120例，按照随机数字表法分为观察组和对照组，各60例 。对照组患者采用低流量氧疗、抗感染、扩张支气管、祛痰等常规治疗；观察组患者在对照组基础上加用清金化痰汤（用400 ml纯净水煎制），tid。观察两组患者治疗前和治疗7 d后痰液白细胞介素（IL）-8、IL-17、IL-23及肿瘤坏死因子α（TNF-α）水平，并比较临床疗效及不良反应发生情况。结果：观察组患者均顺利完成研究，对照组患者有3例脱落。治疗前，两组患者IL-8、IL-17、IL-23、TNF-α水平比较，差异均无统计学意义（P＞0.05）。治疗7 d后，观察组患者IL-8、IL-17、IL-23、TNF-α水平明显降低，且显著低于对照组，差异均有统计学意义（P＜0.05）；对照组患者IL-17、IL-23、TNF-α水平较治疗前明显降低，差异均有统计学意义（P＜0.05），但IL-8水平较治疗前无明显变化，差异无统计学意义（P＞0.05）。观察组患者优良率为95.00％，明显高于对照组的78.95％，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：清金化痰汤治疗AECOPD痰热壅肺证患者疗效显著，能明显改善其炎症因子水平，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Qingjin huatan decoction for patients with AECOPD phlegm-heat obstructing lung. METHODS： 120 patients with AECOPD phlegm-heat obstructing lung were divided into observation group and control group according to random number table， with 60 cases in each group. Control group received routine therapy as low-flow oxygen therapy， anti-infective， bronchiectasis， expectorant， etc.； observation group additionally received Qingjin huatan decoction （decocted by 400 ml pure water）， tid， on the basis of control group. The levels of IL-8， IL-17， IL-23 and TNF-α were observed in 2 groups before and 7 d after treatment. Clinical efficacies and the occurrence of ADR were compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in the levels of IL-8， IL-17， IL-23 and TNF-α between 2 groups （P＞0.05）. After treatment， the levels of IL-8， IL-17， IL-23 and TNF-α in observation group were significantly decreased and lower than in control group， with statistical significance （P＜0.05）. The levels of IL-17， IL-23 and TNF-α in control group were decreased significantly compared to before treatment， with statistical significance （P＜0.05）； the level of IL-8 had no significant change compared to before treatment， without statistical significance （P＞0.05）. Excellent rate of observation group was 95.00％， which was significantly higher than 78.95％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Qingjin huatan decoction shows significant therapeutic efficacy in the treatment of AECOPD phlegm-heat obstructing lung， and can improve inflammatory factors with good safety. |
| 期刊： | 2016年第27卷第35期 |
| 作者： | 张圣浛，邓志刚，张素华 |
| AUTHORS： | ZHANG Shenghan，DENG Zhigang，ZHANG Suhua |
| 关键字： | 慢性阻塞性肺疾病急性加重期；清金化痰汤；痰热壅肺证；炎症因子 |
| KEYWORDS： | Aunte exacerbation of chronic obstructive pulmonary disease； Qingjin huatan decoction； Phlegm-heat obstructing lung； Inflammatory factor |
| 阅读数： | 403 次 |
| 本月下载数： | 1 次 |
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