目的：考察一元促渗剂和多元促渗剂按不同比例联用对吴茱萸超微粉巴布剂的促渗作用，以优选促渗剂及其浓度。方

法：采用改良Franz 扩散池，以离体小鼠腹部皮肤为屏障，采用高效液相色谱法检测一元促渗剂（丙二醇、氮酮、油酸）、多元促渗剂

（丙二醇-氮酮、丙二醇-油酸、丙二醇-氮酮-油酸）及其比例、用量对吴茱萸超微粉巴布剂中吴茱萸碱及吴茱萸次碱单位面积累积渗

透量（Qn）的影响。结果：一元促渗剂丙二醇的促渗效果明显优于其他一元及多元促渗剂，且多元促渗系统中丙二醇所占的比例越

高，对吴茱萸碱及吴茱萸次碱的促渗作用越好；以3％、5％、7％丙二醇为促渗剂时吴茱萸碱的Q36 h分别为11.290、14.332、13.537

μg/cm2，吴茱萸次碱的Q36 h分别为11.965、14.856、13.901 μg/cm2。结论：5％丙二醇的促渗作用最好，可作为吴茱萸超微粉巴布剂的

促渗剂。

OBJECTIVE：To investigate penetrative effects of a penetration enhancer and multiple penetration enhancers combination

with different proportions on Euodia rutaecarpa superfines cataplasm，so as to optimize enhancer and their concentrations.

METHODS：Modified Franz diffusion cell was employed with isolated mice abdominal skin as barrier. HPLC method was adopted

to detect the effects of a penetration enhancer （propanediol，azone，oleic acid），multiple penetration enhancers （propanediol-

azone，propanediol-oleic acid，propanediol-azone-oleic acid），their proportion and amount on accumulative permeation quantity

（Qn）of evodiamine and rutaecarpin in Euodia rutaecarpa superfines cataplasm. RESULTS：The penetrative effect of a penetration

enhancer propanediol was significantly better than that of other one penetration enhancers and multiple penetration enhancers；the

higher proportion of propanediol in multiple penetration enhancer system was，the better penetrative effects of evodiamine and rutaecarpin

had. Using 3％，5 ％ and 7 ％ propanediol as enhancer，Q36 h of evodiamine were 11.290，14.332 and 13.537 μg/cm2，and

those of rutaecarpin were 11.965，14.856 and 13.901 μg/cm2. CONCLUSIONS：The penetrative effect of 5％ propanediol is the

best，and can be used as enhancer for E. rutaecarpa superfines cataplasm.